PI3K signalling

PI3K signalling
Author :
Publisher : Frontiers Media SA
Total Pages : 140
Release :
ISBN-13 : 9782889194193
ISBN-10 : 2889194191
Rating : 4/5 (91 Downloads)

Book Synopsis PI3K signalling by : Klaus Okkenhaug

Download or read book PI3K signalling written by Klaus Okkenhaug and published by Frontiers Media SA. This book was released on 2015-03-05 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.


PI3K signalling Related Books

PI3K signalling
Language: en
Pages: 140
Authors: Klaus Okkenhaug
Categories: Immunologic diseases. Allergy
Type: BOOK - Published: 2015-03-05 - Publisher: Frontiers Media SA

DOWNLOAD EBOOK

The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin,
Encyclopedia of Cancer
Language: en
Pages: 3307
Authors: Manfred Schwab
Categories: Medical
Type: BOOK - Published: 2008-09-23 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and adva
Targeting Cellular Signalling Pathways in Lung Diseases
Language: en
Pages: 926
Authors: Kamal Dua
Categories: Medical
Type: BOOK - Published: 2021-07-02 - Publisher: Springer Nature

DOWNLOAD EBOOK

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various resp
B Cell Receptor Signaling
Language: en
Pages: 233
Authors: Tomohiro Kurosaki
Categories: Medical
Type: BOOK - Published: 2015-12-26 - Publisher: Springer

DOWNLOAD EBOOK

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The fir
Signal Transduction in Cancer
Language: en
Pages: 358
Authors: David A. Frank
Categories: Medical
Type: BOOK - Published: 2002-12-31 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriat