Design of a Near-field Coded Aperture Cameras for High-resolution Medical and Industrial Gamma-ray Imaging

Download or read book Design of a Near-field Coded Aperture Cameras for High-resolution Medical and Industrial Gamma-ray Imaging written by Roberto Accorsi and published by . This book was released on 2001 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Cont.) The main focus of this work is on a coded aperture camera specifically designed for high-resolution single-photon planar imaging with a pre-existing gamma (Anger) camera. Original theoretical findings and the results of computer simulations led to an optimal coded aperture that was tested experimentally in phantom as well as in-vivo studies. Results include, but are not limited to, 1.66-mm-resolution images of 99mTc-labeled blood and bone agents in a mouse. The theoretical bases for extension to sub-millimeter resolution and higher-energy isotopes are also laid and a candidate aperture capable of 0.96-mm resolution proposed. Potential applications are in small-animal imaging, pediatric nuclear medicine and breast imaging, where increased resolution can result in earlier diagnosis of disease. The last Chapter of the thesis extends the ideas developed to the design of a coded aperture suitable for CAFNA (Coded Aperture Fast Neutron Analysis), a contraband detection technique that has been under development at MIT for a number of years.