Studies on Radiation-induced Chimeras

Download or read book Studies on Radiation-induced Chimeras written by L. J. Cole and published by . This book was released on 1962 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present experiments are concerned with the attempt to prevent or ameliorate the occurrence of secondary disease deaths in irradiated mice bearing foreign bone marrow grafts; in addition, certain aspects of graft-to-host tolerance in early radiation chimeras have been investigated. It is concluded that specific graft-to-host tolerance may develop relatively early in radiation chimeras, that it is possible to prevent or eliminate secondary disease in homologous radiation chimeras by suitable preirradiation of the marrow donors, and by injection into the chimeras of specific isoantiserum directed against the marrow donor. (Author).