Replicating Vaccines
Author | : Philip R. Dormitzer |
Publisher | : Springer Science & Business Media |
Total Pages | : 449 |
Release | : 2010-11-02 |
ISBN-13 | : 9783034602778 |
ISBN-10 | : 3034602774 |
Rating | : 4/5 (74 Downloads) |
Download or read book Replicating Vaccines written by Philip R. Dormitzer and published by Springer Science & Business Media. This book was released on 2010-11-02 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.